Faculty

Marcos Sotomayor, PhD

Cnidarian mechanosensory cells as ancestors of vertebrate hair cells: Molecular targeting of an ancient mechanotransduction complex.
Cnidarian mechanosensory cells as ancestors of vertebrate hair cells: Molecular targeting of an ancient mechanotransduction complex. Proc Natl Acad Sci U S A. 2026 Oct 06; 123(40):e2607106123.
PMID: 42804640

Bayesian-Steered Structure Prediction of Mechanical Biomolecules Using Twisted Diffusion.
Bayesian-Steered Structure Prediction of Mechanical Biomolecules Using Twisted Diffusion. bioRxiv. 2026 May 13.
PMID: 42182379

In-Situ ssDNA Isolation from dsDNA Sources as a Streamlined Pathway to DNA Origami Assembly and Testing.
In-Situ ssDNA Isolation from dsDNA Sources as a Streamlined Pathway to DNA Origami Assembly and Testing. bioRxiv. 2026 Mar 23.
PMID: 41929115

PySteMoDA: An Open-Source Python Package for the Analysis of Steered Molecular Dynamics Simulations Data.
PySteMoDA: An Open-Source Python Package for the Analysis of Steered Molecular Dynamics Simulations Data. bioRxiv. 2026 Jan 28.
PMID: 41659591

Structures of invertebrate PEZO-1 isoforms with a compact architecture and a dispensable pore-distal N-terminal blade.
Structures of invertebrate PEZO-1 isoforms with a compact architecture and a dispensable pore-distal N-terminal blade. Cell Rep. 2026 Jan 27; 45(1):116878.
PMID: 41477764

TMC1 and TMC2 are cholesterol-dependent scramblases that regulate membrane homeostasis in auditory hair cells.
TMC1 and TMC2 are cholesterol-dependent scramblases that regulate membrane homeostasis in auditory hair cells. bioRxiv. 2025 Jul 04.
PMID: 40631239

Groove architecture controls lipid scrambling in simulations of protein and model systems.
Groove architecture controls lipid scrambling in simulations of protein and model systems. bioRxiv. 2025 Jul 01.
PMID: 40631228

Structural and functional basis of mechanosensitive TMEM63 channelopathies.
Structural and functional basis of mechanosensitive TMEM63 channelopathies. Neuron. 2025 Aug 06; 113(15):2474-2489.e5.
PMID: 40480214

In silico analyses of molecular force sensors for mechanical characterization of biological systems.
In silico analyses of molecular force sensors for mechanical characterization of biological systems. Biophys J. 2025 03 04; 124(5):829-843.
PMID: 39905731

Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels.
Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels. Elife. 2025 Jan 08; 12.
PMID: 39773557

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